2023
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M. Sharma and E. de Alba. Assembly mechanism of the inflammasome sensor AIM2 revealed by single molecule analysis. Nature Communications. 2023, DOI: 10.1038/s41467-023-43691-4. Link.
E. A. Gaspar-Morales, A. Waterston, M. Sadqi, P. Diaz-Parga, A. M. Smith, A. Gopinath, R. C. Andresen Eguiluz, and E. de Alba. Natural and Engineered Isoforms of the Inflammasome Adaptor ASC Form Noncovalent, pH-Responsive Hydrogels. Biomacromolecules (ACS). DOI: 10.1021/acs.biomac.3c00409. Link. A. Parkins, S. I. Sandin, J. Knittel, A. H. Franz, J. Ren, E. de Alba, G. Pantouris. Underrepresented Impurities in 4-Hydroxyphenylpyruvate Affect the Catalytic Activity of Multiple Enzymes. Anal. Chem. 2023, 95, 11, 4957–4965. Link. |
2022
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P. Diaz-Parga, A. Gould and E. de Alba. Natural and engineered inflammasome adapter proteins reveal optimum linker length for self-assembly. J. Biol. Chem. 2022, 298, 102501. Link.
S. I. Sandin and E. de Alba. Quantitative Studies on the Interaction between Saposin-like Proteins and Synthetic Lipid Membranes. Methods Protoc. 2022, 5(1), 19. Link. P. Diaz-Parga and E. de Alba. Inflammasome regulation by adaptor isoforms, ASC and ASCb, via differential self-assembly. J. Biol. Chem. 2022, 298, 101566. Link. E. de Alba. Methods in Molecular Biology: Protein Folding. Methods and Protocols. Chapter 10: “NMR analysis of protein folding interaction networks”, pag. 173. Ed. Springer Nature. 2022. Link. |
2021
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S.I. Sandin, D.M. Gravano, C.J. Randolph, M. Sharma and E. de Alba. Engineering of saposin C protein chimeras for enhanced cytotoxicity and optimized liposome binding capability. Pharmaceutics 2021, 13, 583. Link
M. Sharma and E. de Alba. Structure, Activation and Regulation of NLRP3 and AIM2 Inflammasomes. Int. J. Mol. Sci. 2021, 22, 872. https://doi.org/10.3390/ ijms22020872. Link |
2020
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E. de Alba. The mysterious role of the NLRP9 pyrin domain in inflammasome assembly. Febs Lett. 2020. Link
D. Pantoja-Uceda, J. Oroz, C. Fernández, E. de Alba, R. Giraldo and D. V. Laurents. Conformational Priming of RepA-WH1 for Functional Amyloid Conversion Detected by NMR Spectroscopy. 2020. Structure, 28 (3), 336-347. Link |
2019
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P. Diaz-Parga and E. de Alba. Chapter: Interactions of the Inflammasome Adapter ASC by solution NMR. DNA Sensors and Inflammasomes. 2019. Methods in Enzymology. 625, 223-252. ISBN 978-0-12-818359-5.
E. de Alba. Structure, Interactions and Self-Assembly of ASC-dependent Inflammasomes. 2019. Archives of Biochemistry and Biophysics: “Inflammasomes - Intracellular Mediators of Immune Defense". 670, 15-31.Link R. J. T. Nambayan, S. I. Sandin, D. A. Quint, David M. Satyadi and E. de Alba. The inflammasome adapter ASC assembles into filaments with integral participation of its two Death Domains, PYD and CARD. 2019. J. Biol. Chem. 294: 439-452. Link Y. He, S. Nagpal, M. Sadqi, E. de Alba, V. Muñoz. Glutton: A tool for generating structural ensembles of partly disordered proteins from chemical shifts. 2019. Bioinformatics. 35, 1234-1236. Link |
2016
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J. Oroz, S. Barrera, C. Alfonso, G. Rivas, E. de Alba. ASC Pyrin domain self-associates and binds NLRP3 protein using equivalent binding interfaces. 2016. J. Biol. Chem. 291, 19487-19501. Link
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2015 |
L. Sborgi, A. Verma, S. Piana, K. Lindorff-Larsen, M. Cerminara, C.M. Santiveri, D.E. Shaw, E. de Alba, V. Muñoz. Interaction networks in protein folding via atomic-resolution experiments and long time-scale molecular dynamics simulations. 2015. J. Am. Chem. Soc. 137, 6506-6516. Link
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